Kincade P W, Medina K L, Smithson G, Scott D C
Oklahoma Medical Research Foundation, Oklahoma City 73104.
Immunol Today. 1994 Nov;15(11):539-44. doi: 10.1016/0167-5699(94)90211-9.
The large-scale production of lymphocytes in the bone marrow reflects a delicate balance between positive and negative regulatory signals. For instance, interleukin 7 (IL-7) provides a positive signal, and appears to be both essential and limiting in the mouse. However, much less is understood concerning the negative molecular signals that may limit the output of lymphocytes. Here, Paul Kincade and colleagues discuss how a chance observation with pregnant mice revealed that sex steroids can act as negative regulators of B lymphopoiesis, and may do so under normal steady-state conditions.
骨髓中淋巴细胞的大规模生成反映了正负调节信号之间的微妙平衡。例如，白细胞介素7（IL-7）提供正信号，在小鼠中似乎既是必需的又是限制性的。然而，对于可能限制淋巴细胞输出的负性分子信号，我们了解得要少得多。在此，保罗·金卡德及其同事讨论了对怀孕小鼠的一次偶然观察如何揭示性类固醇可作为B淋巴细胞生成的负调节因子，并且可能在正常稳态条件下发挥作用。
