Kincade P W
Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Braz J Med Biol Res. 1994 Nov;27(11):2533-8.
Bone marrow culture and molecular cloning techniques have permitted rapid progress to be made in identifying molecules that stimulate or inhibit particular steps in blood cell formation. Two types of factors that influence B lymphocyte precursors are considered in this brief review. Cell adhesion molecules are probably needed to correctly position immature precursors within the marrow and some of the most important of these have been identified. Recent studies suggest that local or systemically derived hormones must also be added to the list of agents which can markedly influence the production of lymphocytes.
骨髓培养和分子克隆技术已使人们在识别刺激或抑制血细胞生成特定步骤的分子方面取得了迅速进展。在这篇简短的综述中，我们考虑了两种影响B淋巴细胞前体的因子。细胞黏附分子可能是将未成熟前体正确定位在骨髓内所必需的，其中一些最重要的分子已被识别出来。最近的研究表明，局部或全身来源的激素也必须被列入能够显著影响淋巴细胞生成的因子清单中。
