Viac J, Schmitt D, Claudy A
Clinique Dermatologique et INSERM U346, Hôpital Edouard Herriot, Lyon.
Allerg Immunol (Paris). 1994 Oct;26(8):274-7.
In inflammatory dermatoses, adhesion molecules are involved in the interaction of leukocytes with endothelial cells, extra-cellular matrix and epidermal cells. In dermatosis where epidermal cells are the main targets of inflammation, the keratinocytes are activated and participate to the local immune reaction through the secretion of cytokines and the expression of the adhesion molecule ICAM-1 and the HLA-DR antigens. Induction of ICAM-1 by IFN gamma or TNF alpha on keratinocytes that do not express this molecule in normal skin may account for the recruitment of T cells into the epidermis. In the dermis, an up-regulation of ICAM-1 expression occurs on endothelial cells activated by cytokines (IL-1, TNF alpha...) and is usually correlated with an induction of ELAM-1 and less frequently VCAM-1. These adhesion molecules are involved in the recruitment of inflammatory cells but also in the control of their retention and migration through the skin.
在炎症性皮肤病中，黏附分子参与白细胞与内皮细胞、细胞外基质及表皮细胞的相互作用。在以表皮细胞为主要炎症靶点的皮肤病中，角质形成细胞被激活，并通过分泌细胞因子以及表达黏附分子细胞间黏附分子-1（ICAM-1）和人类白细胞抗原-DR（HLA-DR）抗原参与局部免疫反应。在正常皮肤中不表达该分子的角质形成细胞上，γ干扰素（IFNγ）或肿瘤坏死因子α（TNFα）诱导ICAM-1表达，这可能是T细胞募集至表皮的原因。在真皮中，细胞因子（白细胞介素-1、TNFα等）激活的内皮细胞上ICAM-1表达上调，且通常与内皮白细胞黏附分子-1（ELAM-1）的诱导相关，而血管细胞黏附分子-1（VCAM-1）的诱导则较少见。这些黏附分子不仅参与炎症细胞的募集，还参与控制它们在皮肤中的滞留和迁移。
