Li X, Sun J, Sun W
PLA General Hospital, Beijing.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1994;29(2):74-7.
The dynamic changes in the CAP, SP and EP in the scale media were examined with single micropipet during anoxia and reventilation with oxygen. Also, the morphologic changes in the IHC, OHC and synapse were observed in this experiment. It was found that the amplitude of the SP and EP values declined with alteration in polarity of these value. The changes in polarity and amplitude of the SP followed the changes of CAP threshold induced by anoxia. The histologic examinations revealed no evidence of acetylcholinesterase (AChE) alteration in the synapse and no succinic dehydrogenase (SDH) changes in IHC appeared. However, the activity of SDH in the OHC decreased. The results suggest that the polarity and amplitude of SP were influenced passively by the changes of EP value. In addition, the changes of SP polarity from positive to negative during anoxia is due to the loss of modulation process of OHC to IHC, while the SP polarity from negative to positive during the supply of oxygen is caused by regain of the modulation process of OHC.
在缺氧和复氧过程中，用单微吸管检测了中耳中CAP、SP和EP的动态变化。此外，在本实验中观察了内毛细胞（IHC）、外毛细胞（OHC）和突触的形态学变化。发现SP和EP值的幅度随这些值极性的改变而下降。SP极性和幅度的变化跟随缺氧诱导的CAP阈值的变化。组织学检查显示突触中没有乙酰胆碱酯酶（AChE）改变的证据，内毛细胞中也没有琥珀酸脱氢酶（SDH）变化。然而，外毛细胞中SDH的活性降低。结果表明，SP的极性和幅度受到EP值变化的被动影响。此外，缺氧期间SP极性从正到负的变化是由于外毛细胞对内毛细胞调制过程的丧失，而供氧期间SP极性从负到正的变化是由外毛细胞调制过程的恢复引起的。
