Wang J A, Dong W J, Chen J S
Fundamental Medical Department, Nanjing Railway Medical College, China.
Hear Res. 1990 Mar;44(2-3):143-9. doi: 10.1016/0378-5955(90)90076-2.
Endocochlear potentials (EPs) were investigated in healthy guinea pigs and in those exposed to white noise of 125 dB SPL for 20-80 min. EPs were measured during and after temporary anoxia (3.5 min, denoted as reversible anoxia) and then during continuous anoxia to evaluate noise-induced changes in EP properties. Succino-dehydrogenase (SDH) activity and morphologic changes in hair cells were also evaluated in surface preparations of the hair cells. It was found that changes in EPs correlated with the duration of noise exposure. The longer the noise exposure, the greater the decrease in EPs. EPs could recover in one week post-exposure, in roughly the same time needed for recovery of SDH activity in hair cells. Noise exposure also resulted in some changes in EP dynamic behaviour during and after reversible anoxia, but did not cause any significant change in maximal negative EP. The mechanisms underlying these results are discussed.
在健康豚鼠以及暴露于125 dB SPL白噪声20 - 80分钟的豚鼠中研究了内耳蜗电位（EPs）。在短暂缺氧（3.5分钟，称为可逆性缺氧）期间和之后测量EPs，然后在持续缺氧期间测量EPs，以评估噪声诱导的EPs特性变化。还在毛细胞的表面制剂中评估了琥珀酸脱氢酶（SDH）活性和毛细胞的形态变化。发现EPs的变化与噪声暴露持续时间相关。噪声暴露时间越长，EPs下降越大。暴露后一周内EPs可恢复，大致与毛细胞中SDH活性恢复所需时间相同。噪声暴露还导致可逆性缺氧期间和之后EPs动态行为发生一些变化，但未引起最大负EPs的任何显著变化。讨论了这些结果的潜在机制。
