Baltaxe H A, Sos T A, McGrath M B
Invest Radiol. 1976 May-Jun;11(3):172-81. doi: 10.1097/00004424-197605000-00004.
Two contrast media (Renografin 76 and Isopaque 370) were used in a double-blind study for coronary angiography and left ventriculography. Fifty-eight patients with presumed coronary artery disease were studied. The effects of the contrast media upon the myocardium and upon ventricular function of patients with and without coronary artery disease were assessed. Pre and post angiography myocardial enzymes were obtained. Cardiac output was determined before and after the angiograms. Hemodynamic and electrocardiographic changes were continuously monitored during the procedure. The study showed that both contrast media produced similar changes; however, the "maximum" decrease in T wave amplitude was more marked in the normal group when Renografin 76 (as compared with Isopaque 370) was injected (p = 0.05) on the right. Renografin 76 injection into the left coronary artery produced a higher median T wave amplitude in lead II relative to Isopaque 370 only in the abnormal group (p = 0.01). The heart rate dropped more severely in the normal patients when the left coronary artery was injected with Renografin 76 than with Isopaque 370 (p = 0.05).
在一项用于冠状动脉造影和左心室造影的双盲研究中使用了两种造影剂（泛影葡胺76和碘番酸370）。对58例疑似患有冠状动脉疾病的患者进行了研究。评估了造影剂对有和没有冠状动脉疾病患者的心肌和心室功能的影响。在血管造影术前和术后获取心肌酶。在血管造影术前和术后测定心输出量。在手术过程中持续监测血流动力学和心电图变化。研究表明，两种造影剂产生了相似的变化；然而，当注射泛影葡胺76（与碘番酸370相比）时，正常组T波振幅的“最大”降低在右侧更为明显（p = 0.05）。仅在异常组中，向左冠状动脉注射泛影葡胺76相对于碘番酸370在II导联产生了更高的T波振幅中位数（p = 0.01）。当向左冠状动脉注射泛影葡胺76时，正常患者的心率下降比注射碘番酸370时更严重（p = 0.05）。
