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[用于识别将纳入结直肠肿瘤传统分期系统的免疫参数的临床实验模型]

[Clinical-experimental models for the identification of immunologic parameters to be integrated in traditional staging systems of colorectal neoplasms].

作者信息

Midiri G, Di Massimo A, Verrico G, Campisi C, Ginis A, Tesoriere A, Covotta L, Parravano C, Castagna G, Colizzi V

机构信息

IV Semeiotica Chirurgica, Università degli Studi, La Sapienza, Roma.

出版信息

G Chir. 1994 Aug-Sep;15(8-9):341-4.

PMID:7803206
Abstract

The Authors evaluate new possible models for the staging of colorectal cancer based on clinico-morphological, histo-pathological and bio-immunological parameters. Particularly, they evaluate the possibility of studying host's immunological response against tumor spread by the examination of the "in situ" cellular responses. This study was performed by cytotoxic test and immunohistochemical evaluation of the lymphocytes. The latter seems to give better results compared to the first in the evaluation of the host's immunological response.

摘要

作者基于临床形态学、组织病理学和生物免疫学参数评估了结直肠癌分期的新的可能模型。特别是,他们通过检查“原位”细胞反应来评估研究宿主针对肿瘤扩散的免疫反应的可能性。这项研究通过细胞毒性试验和淋巴细胞的免疫组织化学评估来进行。在评估宿主免疫反应方面,后者似乎比前者能给出更好的结果。

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G Chir. 1994 Aug-Sep;15(8-9):341-4.
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T-cell response to p53 tumor-associated antigen in patients with colorectal carcinoma.结直肠癌患者中T细胞对p53肿瘤相关抗原的反应。
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