Ferri C, Caracciolo F, Zignego A L, La Civita L, Monti M, Longombardo G, Lombardini F, Greco F, Capochiani E, Mazzoni A
Istituto Patologia Medica I, University of Pisa, Italy.
Br J Haematol. 1994 Oct;88(2):392-4. doi: 10.1111/j.1365-2141.1994.tb05036.x.
Hepatitis C virus (HCV), which is both a hepatotropic and a lymphotropic virus, has been proposed as a possible causative agent of mixed cryoglobulinaemia. This 'benign' lymphoproliferative disorder can switch over to a malignant B-cell non-Hodgkin's lymphoma (NHL). Therefore HCV infection has been investigated in a series of 50 unselected Italian patients with B-cell NHL. Antibodies against HCV were found in 30% of NHL and HCV viraemia in 32% of cases. HCV-related markers were detected in 34% (17/50) of our NHL patients; this prevalence is particularly significant when compared with HCV seropositivity in Hodgkin's lymphoma (3%) and healthy controls (1.3%).
丙型肝炎病毒（HCV）既是嗜肝病毒又是嗜淋巴细胞病毒，有人提出它可能是混合性冷球蛋白血症的致病因子。这种“良性”淋巴增殖性疾病可转变为恶性B细胞非霍奇金淋巴瘤（NHL）。因此，我们对50例未经挑选的意大利B细胞NHL患者进行了HCV感染调查。在30%的NHL患者中发现了抗HCV抗体，32%的病例存在HCV病毒血症。在我们的50例NHL患者中，34%（17/50）检测到了HCV相关标志物；与霍奇金淋巴瘤（3%）和健康对照（1.3%）的HCV血清阳性率相比，这一患病率尤为显著。
