Bianco Elvira, Marcucci Fabrizio, Mele Alfonso, Musto Pellegrino, Cotichini Rodolfo, Sanpaolo Maria Grazia, Iannitto Emilio, De Renzo Amalia, Martino Bruno, Specchia Giorgina, Montanaro Marco, Barbui Anna Maria, Nieddu Rosa, Pagano Livio, Rapicetta Maria, Franceschi Silvia, Mandelli Franco, Pulsoni Alessandro
Istituto Superiore di Sanità, Rome, Italy.
Haematologica. 2004 Jan;89(1):70-6.
Infection with hepatitis C virus (HCV) is associated with type II mixed cryoglobulinemia (MC), a lymphoproliferative disorder which, in some patients, evolves into overt B-cell non-Hodgkin's lymphoma (B-NHL). Recently, also the association between HCV infection and B-NHL, which had long been controversial, was confirmed in a large case-control study. Little knowledge is, however, available on possible associations between HCV infection and other lymphoid or myeloid malignancies. The present study was set up in order to investigate this aspect.
The study was conducted in hematology departments of ten hospitals in different Italian cities. The cases consisted of consecutive patients with a new diagnosis of T-NHL, Hodgkin's disease (HD), chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), multiple myeloma (MM), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). The controls were patients in other departments of the same hospitals. HCV infection was investigated by testing for HCV antibodies and HCV-RNA in serum samples.
The prevalence of HCV infection was not higher in patients with HD (3.2%, 5 out of 157 cases) or MM (4.7%, 5 out of 107) than in controls. On the other hand, it was consistently higher in T-NHL (13.8%, 4 out of 30), CLL (9.0%, 9 out of 100), ALL (7.6%, 5 out of 54), AML (7.9%, 11 out of 140), and CML (12.2%, 6 out of 49) patients. These patient groups were not, however, large enough to render statistically significant results.
Our data suggest that HCV infection may be associated not only with B-NHL but also with some other lymphoid and myeloid malignancies.
丙型肝炎病毒（HCV）感染与II型混合性冷球蛋白血症（MC）相关，MC是一种淋巴增殖性疾病，在某些患者中会发展为明显的B细胞非霍奇金淋巴瘤（B-NHL）。最近，长期存在争议的HCV感染与B-NHL之间的关联在一项大型病例对照研究中也得到了证实。然而，关于HCV感染与其他淋巴或髓系恶性肿瘤之间可能存在的关联，人们了解甚少。本研究旨在调查这一方面。
该研究在意大利不同城市的十家医院的血液科进行。病例包括新诊断为T-NHL、霍奇金病（HD）、慢性淋巴细胞白血病（CLL）、急性淋巴细胞白血病（ALL）、多发性骨髓瘤（MM）、急性髓系白血病（AML）和慢性髓系白血病（CML）的连续患者。对照为同医院其他科室的患者。通过检测血清样本中的HCV抗体和HCV-RNA来调查HCV感染情况。
HD患者（3.2%，157例中有5例）或MM患者（4.7%，107例中有5例）的HCV感染患病率并不高于对照组。另一方面，T-NHL患者（13.8%，30例中有4例）、CLL患者（9.0%，100例中有9例）、ALL患者（7.6%，54例中有5例）、AML患者（7.9%，140例中有11例）和CML患者（12.2%，49例中有6例）的HCV感染患病率始终较高。然而，这些患者组规模不够大，无法得出具有统计学意义的结果。
我们的数据表明，HCV感染可能不仅与B-NHL有关，还与其他一些淋巴和髓系恶性肿瘤有关。
