Ljungman P, Lawler M, Asjö B, Bogdanovic G, Karlsson K, Malm C, McCann S R, Ringdén O, Gahrton G
Department of Medicine, Huddinge University Hospital, Sweden.
Br J Haematol. 1994 Oct;88(2):403-5. doi: 10.1111/j.1365-2141.1994.tb05040.x.
Human T lymphotrophic virus type 1 (HTLV-I) associated leukaemia has a poor prognosis even with chemotherapy. We describe a patient with adult T-cell leukaemia treated with allogeneic bone marrow transplantation from an HTLV-I negative identical sibling donor. During follow-up after bone marrow transplantation, HTLV-I could be repeatedly isolated inspite of anti-viral prophylaxis. The patient died of an acute encephalitis and HTLV-I could be detected in autopsy material from the brain. By a PCR-based technique using short tandem repeats (STRs) it was shown that the patient's haemopoiesis was of donor origin. This shows the infection of donor cells in vivo by an aetiological agent which has been implicated in the leukaemogenic process for adult T-cell leukaemia.
人类嗜T淋巴细胞病毒1型（HTLV-I）相关白血病即使接受化疗，预后也很差。我们描述了一名患有成人T细胞白血病的患者，接受了来自HTLV-I阴性同卵同胞供体的异基因骨髓移植治疗。在骨髓移植后的随访期间，尽管进行了抗病毒预防，仍能反复分离出HTLV-I。患者死于急性脑炎，在大脑的尸检材料中可检测到HTLV-I。通过基于短串联重复序列（STRs）的聚合酶链反应（PCR）技术表明，患者的造血功能源自供体。这表明致病因子在体内感染了供体细胞，而该致病因子与成人T细胞白血病的白血病发生过程有关。
