Garety P A, Kuipers L, Fowler D, Chamberlain F, Dunn G
Department of Psychology, Institute of Psychiatry, London, UK.
Br J Med Psychol. 1994 Sep;67(3):259-71. doi: 10.1111/j.2044-8341.1994.tb01795.x.
A small controlled trial of cognitive behaviour therapy for drug-resistant psychosis is reported. The study was designed as a pilot study for a future larger and longer randomized controlled trial. The therapy was offered to patients with a diagnosis of schizophrenia or schizo-affective psychosis who presented unremitting positive symptoms. An average of 16 sessions were delivered over a six-month period. The results of this pilot study are promising. Rates of engagement in therapy were high. The treatment group also improved significantly on a number of key symptom measures when compared with the controls. These were reductions in delusional conviction, general symptomatology and depression scores. Future studies should offer therapy over a longer period, targeting social as well as symptom change, and considering factors which will enhance maintenance of improvement.
本文报告了一项针对耐药性精神病的认知行为疗法小型对照试验。该研究被设计为未来一项更大规模、更长时间的随机对照试验的预试验。该疗法提供给被诊断为精神分裂症或分裂情感性精神病且存在持续阳性症状的患者。在六个月的时间里平均进行了16次治疗。这项预试验的结果很有前景。治疗参与率很高。与对照组相比，治疗组在一些关键症状指标上也有显著改善。这些指标包括妄想信念、总体症状和抑郁评分的降低。未来的研究应在更长时间内提供治疗，以社会改变以及症状改变为目标，并考虑能够促进改善维持的因素。
