Biology of EWS/FLI and related fusion genes in Ewing's sarcoma and primitive neuroectodermal tumor.

作者信息

May W A, Denny C T

机构信息

Department of Pediatrics, Gwynne Hazen Cherry Memorial Laboratories, School of Medicine, University of California, Los Angeles 90024, USA.

出版信息

Curr Top Microbiol Immunol. 1997;220:143-50.

PMID:9103680

Abstract

摘要

相似文献

Biology of EWS/FLI and related fusion genes in Ewing's sarcoma and primitive neuroectodermal tumor.

Curr Top Microbiol Immunol. 1997;220:143-50.

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.EWS-Fli1反义寡脱氧核苷酸抑制人尤因肉瘤和原始神经外胚层肿瘤细胞的增殖。

J Clin Invest. 1997 Jan 15;99(2):239-47. doi: 10.1172/JCI119152.

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma.在尤因肉瘤中，EWS/FLI介导的致癌表型需要NR0B1。

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Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors.多种染色体机制在尤因肿瘤中产生EWS/FLI1或EWS/ERG融合基因。

Cancer Genet Cytogenet. 1997 Aug;97(1):12-9. doi: 10.1016/s0165-4608(96)00326-3.

In situ reverse-transcriptase polymerase chain reaction demonstration of the EWS/FLI-1 fusion transcript in Ewing's sarcomas and peripheral primitive neuroectodermal tumors.原位逆转录酶聚合酶链反应证实尤因肉瘤和外周原始神经外胚层肿瘤中EWS/FLI-1融合转录本的存在

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[Detection of EWS-/FLI-1 gene fusion transcripts by RT-PCR as a tool in the diagnosis of tumors of the Ewing sarcoma group].[通过逆转录聚合酶链反应检测EWS-/FLI-1基因融合转录本作为尤因肉瘤组肿瘤诊断工具]

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A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.尤文肉瘤细胞中碱性成纤维细胞生长因子（bFGF）与EWS/FLI-1之间的联系。

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PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.血小板源性生长因子C是尤因家族肿瘤中一种由EWS/FLI诱导的转化生长因子。

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Biphenotypic sarcomas with myogenic and neural differentiation express the Ewing's sarcoma EWS/FLI1 fusion gene.具有肌源性和神经分化的双表型肉瘤表达尤因肉瘤EWS/FLI1融合基因。

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RT-PCR evaluation of peripheral blood, bone marrow and peripheral blood stem cells in children and adolescents undergoing VACIME chemotherapy for Ewing's sarcoma and alveolar rhabdomyosarcoma.对接受VACIME化疗的尤文肉瘤和肺泡横纹肌肉瘤患儿及青少年的外周血、骨髓和外周血干细胞进行逆转录聚合酶链反应评估。

Bone Marrow Transplant. 1999 Sep;24(5):527-33. doi: 10.1038/sj.bmt.1701939.

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The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function.致癌性EWS-FLI1蛋白在体内与具有潜在转录激活功能的GGAA微卫星序列结合。

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PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.血小板源性生长因子C是尤因家族肿瘤中一种由EWS/FLI诱导的转化生长因子。

Oncogene. 2001 Feb 1;20(5):626-33. doi: 10.1038/sj.onc.1204133.

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