Vukmir R B, Kusne S, Linden P, Pasculle W, Fothergill A W, Sheaffer J, Nieto J, Segal R, Merhav H, Martinez A J
Department of Anesthesiology, University of Pittsburgh Medical Center, Pennsylvania.
Clin Infect Dis. 1994 Oct;19(4):714-9. doi: 10.1093/clinids/19.4.714.
A 68-year-old liver transplant recipient who was being treated with FK 506 and immunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.
一名68岁的肝移植受者正在接受FK506和免疫抑制类固醇治疗，因强直阵挛性发作入住我们的医疗中心。头部计算机断层扫描显示多个散在的脑脓肿，术中引流液培养出一种暗色真菌。该分离株对两性霉素B和伊曲康唑敏感，但对氟胞嘧啶和氟康唑耐药。患者接受了长时间的两性霉素B胶体分散液和伊曲康唑治疗，在2年的随访中，疾病的临床和影像学表现均得到缓解，治疗成功。
