Palomo Cobos L
Unidad de Investigación, Hospital San Pedro de Alcántara, Cáceres.
Aten Primaria. 1994 Sep 15;14(4):707-10.
To check if antitetanus immunity after a correct vaccination lasts the anticipated 10 years.
Sero-epidemiological crossover study. Determination of tetanus antitoxin by the ELISA method.
The town of Barrado in Cáceres.
136 adult men and women (average age 54.6 +/- 15.9 years; range, 24 to 87) who had received their most recent vaccination during a 1981-1982 campaign. 71.32% received three doses.
82.35% +/- 6.40 of the sera analysed (percentage +/- C.I. 95%) maintained adequate levels of protection (> or = 0.01 Ui/ml). 100% of those under 35, revaccinated in 1980-81 because they were ELISA negative in spite of earlier school vaccination, were protected. The average concentrations did not differ significantly by gender and age-groups, although a tendency to decrease with age was noted.
Anti-tetanus vaccination in the individuals studied provided lasting protection, detectable for 10 years in 76-89% of cases. This level of effectiveness lends support to the criterion of administering back-up doses every 10 years.
检查正确接种疫苗后的抗破伤风免疫力是否能持续预期的10年。
血清流行病学交叉研究。采用ELISA法测定破伤风抗毒素。
卡塞雷斯省的巴拉多镇。
136名成年男女（平均年龄54.6±15.9岁；范围24至87岁），他们在1981 - 1982年的疫苗接种活动中接受了最近一次疫苗接种。71.32%的人接种了三剂。
分析的血清中有82.35%±6.40（百分比±95%置信区间）维持了足够的保护水平（≥0.01 Ui/ml）。1980 - 1981年重新接种疫苗的35岁以下人群，尽管早期学校接种时ELISA检测为阴性，但100%受到了保护。平均浓度在性别和年龄组之间没有显著差异，不过注意到有随年龄下降的趋势。
在所研究的个体中，破伤风疫苗接种提供了持久的保护，在76 - 89%的病例中可检测到长达10年。这种有效性水平支持了每10年接种加强剂量的标准。
