Link T M, Kerber S, Fechtrup C, Pöppelmann M, Kleinen T, Blasius S, Budde T, Breithardt G, Peters P E
Institut für Klinische Radiologie, Westfälischen Wilhelms-Universität Münster.
Rofo. 1994 Dec;161(6):540-6. doi: 10.1055/s-2008-1032582.
The aim of this in vitro study was to analyze the diagnostic performance of intravascular ultrasound (IVUS) in vessel wall calcifications and to compare the accuracy of mechanical 12.5 and 20 MHz transducers. Fourty-three sections of 10 vessels with signs of arteriosclerotic disease on pathologic examination were examined. Slices 500 microns thick were obtained and examined radiographically at 9 fold magnification. In each section, identical segments were defined, amounting to a total of 344 segments. The IVUS sections were analyzed by 3 experienced readers. For statistical evaluation ROC analysis was performed using magnification radiography as a reference. An area under the curve (AUC) of 0.79 was obtained for the 12.5 transducer and of 0.83 for the 20 MHz transducer. Additionally, sensitivity, specificity, and accuracy were determined. Sensitivity depended on the morphology, size, and density of the calcified lesions. We therefore conclude that the sensitivity of intravascular ultrasound concerning calcified arteriosclerotic plaques is limited and that there is no significant (p < 0.01) difference between mechanical 20 and 12.5 MHz transducers in examining iliac arteries.
本体外研究的目的是分析血管内超声（IVUS）在血管壁钙化方面的诊断性能，并比较12.5MHz和20MHz机械换能器的准确性。对10条经病理检查有动脉粥样硬化疾病迹象的血管的43个切片进行了检查。获取了500微米厚的切片，并在9倍放大率下进行放射照相检查。在每个切片中，定义了相同的节段，总共344个节段。3位经验丰富的读者对IVUS切片进行了分析。为了进行统计评估，以放大放射照相作为参考进行ROC分析。12.5MHz换能器的曲线下面积（AUC）为0.79，20MHz换能器的AUC为0.83。此外，还确定了敏感性、特异性和准确性。敏感性取决于钙化病变的形态、大小和密度。因此，我们得出结论，血管内超声对钙化动脉粥样硬化斑块的敏感性有限，并且在检查髂动脉时，20MHz和12.5MHz机械换能器之间没有显著（p<0.01）差异。
