Meine M, Machraoui A, Dasbach G, Lemke B, Dryander S, Müller K M, Barmeyer J
Abteilung für Biomedizinische Technik, Ruhr-Universität Bochum.
Z Kardiol. 1997 Oct;86(10):818-26. doi: 10.1007/s003920050120.
The aim of this study was to validate the detection of calcified arteriosclerotic plaques with intravascular ultrasound (IVUS).
181 arteries were examined by 20/30 MHz IVUS. The ultrasound cross-sections were compared to the corresponding radiologic (30 kV) and histologic cross-sections.
Calcified lesions were imaged as bright echos with shadowing. In 13 cases of 161 calcified lesions were too small to detect by IVUS. In 5 ultrasonic sections the diagnosis "calcified lesion" could not be verified neither by radiology nor by histology. The sensitivity was 91.6%, the specificity was 94.7% and the accuracy was 93.0%.
Because of the acoustic properties of calcium, calcified lesions can be detected accurately by IVUS. IVUS can generate new insights into the effect of plaque composition on the response to catheter therapies.
本研究旨在验证血管内超声（IVUS）对钙化动脉粥样硬化斑块的检测能力。
采用20/30 MHz的IVUS对181条动脉进行检查。将超声横截面与相应的放射学（30 kV）和组织学横截面进行比较。
钙化病变表现为伴有声影的明亮回声。在161处钙化病变中，有13处因太小而无法被IVUS检测到。在5个超声切片中，“钙化病变”的诊断既无法通过放射学也无法通过组织学得到证实。敏感性为91.6%，特异性为94.7%，准确性为93.0%。
由于钙的声学特性，IVUS能够准确检测出钙化病变。IVUS可以为斑块成分对导管治疗反应的影响提供新的见解。
