Wintermeyer S M, Nahata M C
Ohio State University, Columbus.
Ann Pharmacother. 1994 Sep;28(9):1089-99. doi: 10.1177/106002809402800915.
To review various aspects of chronic suppurative otitis media (CSOM).
A MEDLINE search and extensive review of articles provided the information for this review.
Studies describing the epidemiology, microbiology, risk factors, pathology, diagnosis, treatment, complications, and recurrence of CSOM were included.
Pseudomonas aeruginosa and anaerobes are the most predominant bacteria found in CSOM. Treatment with otic, oral, or parenteral drugs (e.g., neomycin/polymyxin B/hydrocortisone otic, ciprofloxacin, ceftazidime, or aminoglycosides) should be guided by ear fluid culture results. Prompt treatment with effective and safe antibiotics may prevent complications of CSOM.
Treatment of CSOM has improved as a result of availability of effective otic and oral antibiotics. Treatment of the anaerobic infection with antibiotics should be studied further.
综述慢性化脓性中耳炎（CSOM）的各个方面。
通过医学文献数据库（MEDLINE）检索及对文章的广泛回顾获取本综述所需信息。
纳入描述CSOM的流行病学、微生物学、危险因素、病理学、诊断、治疗、并发症及复发情况的研究。
铜绿假单胞菌和厌氧菌是CSOM中最主要的细菌。耳用、口服或胃肠外用药（如新霉素/多粘菌素B/氢化可的松耳用制剂、环丙沙星、头孢他啶或氨基糖苷类）的治疗应依据耳液培养结果来指导。及时使用有效且安全的抗生素可预防CSOM的并发症。
由于有效耳用和口服抗生素的可得性，CSOM的治疗已有改善。抗生素对厌氧菌感染的治疗有待进一步研究。
