Wolgemuth D J, Rhee K, Ravnik S E
Department of Genetics and Development, Columbia University College of Physicians and Surgeons, NY, NY 10032.
Contracept Fertil Sex. 1994 Oct;22(10):623-6.
Understanding the genetic program that controls the regulation of cells progressing through the mitotic and meiotic cell cycles, whether in response to growth factors, other extracellular signals, or intrinsic programs, is critical to problems in infertility and in gonadal neoplasias. In this study, we present a consideration of important stages of cell cycle control in mammalian germ cells and data illustrating the experimental approaches that can be used to determine the pattern of such genes which may be involved in these events.
了解控制细胞通过有丝分裂和减数分裂细胞周期进行调控的遗传程序，无论其是对生长因子、其他细胞外信号还是内在程序作出反应，对于解决不孕症和性腺肿瘤问题都至关重要。在本研究中，我们探讨了哺乳动物生殖细胞中细胞周期控制的重要阶段，并给出了相关数据，这些数据说明了可用于确定可能参与这些事件的此类基因模式的实验方法。
