Katayanagi K, Terada T, Nakanuma Y, Ueno T
Second Department of Pathology, School of Medicine, Kanazawa University, Japan.
Pathol Int. 1994 Sep;44(9):704-11. doi: 10.1111/j.1440-1827.1994.tb02950.x.
A case of pseudolymphoma (reactive lymphoid hyperplasia) of the liver in a 66 year old female is presented. A tumor-like lesion was incidentally discovered in the liver during clinical follow up of diabetes mellitus. The hepatic lesion was resected because malignant lymphoma was suspected after a needle biopsy. Grossly, the lesion was well-defined and measured 1.0 x 1.5 x 1.0 cm. Microscopically, the lesion consisted of hyperplastic lymphoid follicles with distinctive germinal centers and interfollicular areas consisting of mature lymphocytes and plasma cells. An immunohistological study revealed that the lymphoid cells of the lesion were polyclonal in immunophenotypes. These histological and immunohistochemical findings strongly suggested a pseudolymphoma and not hepatic inflammatory pseudotumor. This case was diagnosed as pseudolymphoma of liver. Only a few cases of hepatic pseudolymphoma have so far been reported in the English literature.
本文报告一例66岁女性肝脏假性淋巴瘤（反应性淋巴组织增生）。在糖尿病临床随访期间，偶然在肝脏发现一个肿瘤样病变。经针吸活检怀疑为恶性淋巴瘤后，对肝脏病变进行了切除。大体上，病变边界清晰，大小为1.0×1.5×1.0厘米。显微镜下，病变由具有独特生发中心的增生性淋巴滤泡和由成熟淋巴细胞及浆细胞组成的滤泡间区域构成。免疫组织学研究显示，病变的淋巴细胞免疫表型为多克隆性。这些组织学和免疫组化结果强烈提示为假性淋巴瘤而非肝脏炎性假瘤。该病例被诊断为肝脏假性淋巴瘤。迄今为止，英文文献中仅报道了少数几例肝脏假性淋巴瘤病例。
