Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Nakamura S, Ishizaki T
Pathology Section, Kanazawa University Hospital, Japan.
Pathol Res Pract. 1996 Feb;192(2):166-9; discussion 170-1. doi: 10.1016/S0344-0338(96)80213-5.
An unusual case of pseudolymphoma of the thyroid gland is presented. A well-demarcated whitish mass measuring 1.0 cm in diameter was found in the upper center of the right lobe of the thyroid gland. Microscopically, the lesion was composed of hyperplastic lymphoid tissues with many follicular centers and mixed infiltration of plasma cells and macrophages. The immunostain revealed a similar distribution of T-and B-lymphocytes to reactive lymph node and a polyclonal nature of the plasma cell infiltrates. No lymphoepithelial lesion was associated. The adjacent thyroid tissues showed chronic lymphocytic thyroiditis. This finding suggests that the lesion is a pseudolymphoma of the thyroid gland. This condition is rare, but it should be considered during the differential diagnosis of lymphoproliferative lesions occurring in the thyroid gland, especially with low-grade malignant lymphoma of the thyroid gland.
本文报告了一例罕见的甲状腺假淋巴瘤病例。在甲状腺右叶上中部发现一个边界清晰的白色肿物，直径为1.0厘米。显微镜下，病变由增生的淋巴组织构成，有许多滤泡中心，并伴有浆细胞和巨噬细胞的混合浸润。免疫染色显示T淋巴细胞和B淋巴细胞的分布与反应性淋巴结相似，浆细胞浸润具有多克隆性。未发现淋巴上皮病变。相邻的甲状腺组织显示慢性淋巴细胞性甲状腺炎。这一发现提示该病变为甲状腺假淋巴瘤。这种情况很罕见，但在甲状腺发生的淋巴增殖性病变的鉴别诊断中，尤其是与甲状腺低级别恶性淋巴瘤鉴别时，应予以考虑。
