De Lima M D, Kohlmann N E, Neves F A, Zanella M T, Ribeiro A B, Kohlmann O
Nephrology Division, Escola Paulista de Medicina, São Paulo, Brazil.
Blood Press Suppl. 1994;4:53-6.
In this study, 14 mild-to-moderate essential hypertensive patients of both sexes were studied with regard to the effects of two different treatments, urapidil (60 to 180 mg/day) and diuretics (chlorthalidone and hydrochlorothiazide-25 to 50 mg/day) on glucose metabolism, insulin sensitivity and plasma lipid profile. Blood pressure was equally reduced by both treatments. However, urapidil treatment was accompanied by significant lower plasma levels of cholesterol, HDL-cholesterol and triglycerides as compared with diuretic treatment. Also, a significantly higher insulin sensitivity index, determined by the euglycemic insulin clamp technique, was observed during urapidil therapy. Our results demonstrated that urapidil is as effective as diuretics in reducing blood pressure of essential hypertensive patients, with the potential advantage of a favorable profile in regard to the glucose and lipid metabolisms.
在本研究中，对14例轻度至中度原发性高血压患者（男女均有）进行了研究，观察两种不同治疗方法，即乌拉地尔（60至180毫克/天）和利尿剂（氯噻酮和氢氯噻嗪 - 25至50毫克/天）对糖代谢、胰岛素敏感性和血浆脂质谱的影响。两种治疗方法均能使血压同等程度降低。然而，与利尿剂治疗相比，乌拉地尔治疗伴随血浆胆固醇、高密度脂蛋白胆固醇和甘油三酯水平显著降低。此外，在乌拉地尔治疗期间，通过正常血糖胰岛素钳夹技术测定的胰岛素敏感性指数显著更高。我们的结果表明，乌拉地尔在降低原发性高血压患者血压方面与利尿剂同样有效，在糖和脂质代谢方面具有有利特征的潜在优势。
