Pearson J D
Vascular Biology Research Centre, Biomedical Sciences Division, King's College London, UK.
Br Med Bull. 1994 Oct;50(4):776-88. doi: 10.1093/oxfordjournals.bmb.a072925.
Endothelial cells are responsible for the secretion or surface expression of a wide variety of mediators involved in the control of thrombosis. These include von Willebrand factor, prostacyclin, nitric oxide, thrombomodulin, tissue-type plasminogen activator and its inhibitor, tissue factor and the tissue factor pathway inhibitor. The production of each of these can be modulated; in some cases very rapidly in response to external stimuli, in other cases more slowly. Thrombin is a key stimulus, which affects the production of almost all of these mediators. In addition, several cytokines and bacterial endotoxins shift the balance of endothelial mediator secretion from the basal anticoagulant profile towards a procoagulant profile.
内皮细胞负责分泌或在表面表达多种参与血栓形成控制的介质。这些介质包括血管性血友病因子、前列环素、一氧化氮、血栓调节蛋白、组织型纤溶酶原激活物及其抑制剂、组织因子和组织因子途径抑制剂。这些介质的产生均可被调节；在某些情况下，可对外界刺激做出非常快速的反应，而在其他情况下则较为缓慢。凝血酶是一种关键刺激物，几乎影响所有这些介质的产生。此外，几种细胞因子和细菌内毒素会使内皮介质分泌的平衡从基础抗凝状态转向促凝状态。
