Murer H, Biber J
Institute of Physiology, University of Zürich, Switzerland.
Curr Opin Nephrol Hypertens. 1994 Sep;3(5):504-10. doi: 10.1097/00041552-199409000-00005.
Proximal tubular reabsorption of inorganic phosphate (P(i) is a major determinant of the extracellular concentration of phosphate. The net proximal reabsorption of phosphate largely depends on the rate of apical sodium-dependent transport of P(i) (Na/P(i) cotransport), which is controlled by various hormonal and nonhormonal factors. Renal Na/P(i) cotransport systems that represent proximal apical Na/P(i) cotransport systems have recently been identified. Molecular knowledge of proximal tubular Na/P(i) cotransport will lead to a new understanding of the cellular mechanisms of the physiologic control of proximal P(i) reabsorption and to elucidation of the pathophysiologic mechanisms impairing P(i) homeostasis.
近端肾小管对无机磷酸盐（P(i)）的重吸收是细胞外磷酸盐浓度的主要决定因素。磷酸盐的近端净重吸收很大程度上取决于顶端钠依赖性P(i)转运（钠/磷酸盐共转运）的速率，该转运受多种激素和非激素因素的控制。代表近端顶端钠/磷酸盐共转运系统的肾脏钠/磷酸盐共转运系统最近已被确定。近端肾小管钠/磷酸盐共转运的分子知识将有助于重新认识近端P(i)重吸收生理控制的细胞机制，并阐明损害P(i)稳态的病理生理机制。
