Greenwald P, Kelloff G, Burch-Whitman C, Kramer B S
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland.
CA Cancer J Clin. 1995 Jan-Feb;45(1):31-49. doi: 10.3322/canjclin.45.1.31.
Chemoprevention has been shown to be an extremely promising approach to the prevention of invasive cancer. Through the identification of chemopreventive agents that inhibit or reverse the process of carcinogenesis, new strategies of early intervention can be developed for patients at high risk that potentially prevent the onset of invasive and metastatic phases of cancer. This articles reviews the present efforts in chemoprevention research, including the identification of promising agents, screening, and preclinical and clinical evaluations.
化学预防已被证明是预防浸润性癌症的一种极有前景的方法。通过鉴定抑制或逆转致癌过程的化学预防剂，可以为高危患者开发早期干预的新策略，从而有可能预防癌症浸润和转移阶段的发生。本文综述了化学预防研究的现状，包括有前景的药物的鉴定、筛选以及临床前和临床评估。
