Goihman-Yahr M
Department of Dermatology, Vargas School of Medicine, Central University of Venezuela, Caracas.
Dermatol Clin. 1994 Oct;12(4):703-12.
American mucocutaneous leishmaniasis is produced by several species of Leishmania. The microorganism lives in jungle reservoirs and is transmitted by sandflies. After infection, a complex set of immunologic phenomena takes place. Most lesions tend to heal, but some clinical forms are relentlessly progressive and resistant to available therapy. Diagnosis is usually possible with classical or modern techniques. Current treatment is effective in most cases, but it is expensive and difficult to manage under field conditions. Research on the immune response has been interesting, and vaccine prevention and treatment are objects of current interest. American leishmaniasis may not always remain a sylvan disease, and urban adaptation is a distressing possibility.
美洲皮肤利什曼病由几种利什曼原虫引起。该微生物存在于丛林疫源地，通过白蛉传播。感染后会发生一系列复杂的免疫现象。大多数病变倾向于自愈，但有些临床类型会持续进展且对现有治疗有抗性。通常可用经典或现代技术进行诊断。目前的治疗在大多数情况下有效，但费用高昂且在野外条件下难以管理。对免疫反应的研究很有意思，疫苗预防和治疗是当前关注的对象。美洲利什曼病可能不会一直局限于森林疾病，其适应城市环境是令人担忧的一种可能性。
