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饮食因素与肾结石形成

Dietary factors and kidney stone formation.

作者信息

Curhan G C, Curhan S G

机构信息

Brockton/West Roxbury VA Medical Center, MA 02132.

出版信息

Compr Ther. 1994;20(9):485-9.

PMID:7805364
Abstract

Kidney stone disease is a substantial health problem associated with significant pain and suffering, as well as economic costs. Over $2 billion were spent in 1986 on stone disease, the majority on treatment of existing stones and only a small percentage on prevention. Clearly, efforts to prevent or at least reduce the likelihood of developing a kidney stone would be an important component of the care of patients at risk. In particular, modifiable dietary factors appear to play an important role in the formation of calcium oxalate stones--the type of stone formed in the vast majority of cases. Once secondary causes of stone formation, such as hyperparathyroidism and renal tubular acidosis, are excluded, dietary counselling is a prudent and effective element of the therapeutic regimen and kidney stone prevention program. Specifically, for individuals who have a history of a calcium-containing kidney stone, important dietary recommendations should include the following: Achieve adequate fluid intake to produce at least 2 liters of urine per day. Avoid calcium restriction (except in the rare instances of excessive intake of greater than several grams per day). It is recommended a dietary intake of elemental calcium of at least 800 mg/day (the current RDA for adults) to prevent a negative calcium balance, bone mineral loss, and increased intestinal absorption of oxalate. At present, there is no evidence to support the belief that calcium restriction is beneficial and current data suggest that it may in fact be harmful.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

肾结石病是一个严重的健康问题,会带来巨大的痛苦,还会产生经济成本。1986年,用于结石病的花费超过20亿美元,大部分用于现有结石的治疗,只有一小部分用于预防。显然,预防或至少降低患肾结石可能性的努力将是对有风险患者护理的重要组成部分。特别是,可改变的饮食因素似乎在草酸钙结石的形成中起重要作用——绝大多数病例中形成的结石类型。一旦排除结石形成的继发原因,如甲状旁腺功能亢进和肾小管酸中毒,饮食咨询就是治疗方案和肾结石预防计划中谨慎且有效的一部分。具体而言,对于有含钙肾结石病史的个体,重要的饮食建议应包括以下内容:摄入足够的液体,每天至少产生2升尿液。避免限制钙的摄入(除非每天摄入超过几克这种罕见的过量情况)。建议饮食中元素钙的摄入量至少为800毫克/天(目前成年人的推荐膳食摄入量),以防止钙负平衡、骨矿物质流失以及草酸肠道吸收增加。目前,没有证据支持限制钙摄入有益的观点,现有数据表明这样做实际上可能有害。(摘要截选至250字)

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