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帕金森病认知功能减退的证据有多令人信服?

How convincing is the evidence for cognitive slowing in Parkinson's disease?

作者信息

Howard L A, Binks M G, Moore A P, Playfer J R

机构信息

University of Liverpool, England.

出版信息

Cortex. 1994 Sep;30(3):431-43. doi: 10.1016/s0010-9452(13)80339-5.

Abstract

The issue of whether or not Parkinson's disease (PD) patients process information more slowly than normal is unresolved. Across a range of paradigms the evidence for slowing is scant, and many show no slowing. Even the results of a single experimental paradigm can be conflicting; some studies have obtained evidence for slowed memory scanning in subgroups of PD patients whereas others have not. The present study sought the cause of these discrepant results. Old-old (n = 11) and young-old (n = 7) PD subjects and controls (n = 16, n = 9) completed both fixed and varied set versions of the memory scanning task. No evidence for slowing in PD was found. These results indicated that PD did not interact with age or task version in its effects on information processing rates in the memory scanning task. It was concluded that PD patients do not have any cognitive slowing that is detectable with the memory scanning task.

摘要

帕金森病(PD)患者处理信息的速度是否比正常人慢这一问题尚无定论。在一系列范式中,支持信息处理速度减慢的证据很少,而且许多研究并未显示出减慢的情况。即使是单一实验范式的结果也可能相互矛盾;一些研究在PD患者亚组中获得了记忆扫描减慢的证据,而另一些研究则没有。本研究探寻了这些矛盾结果的原因。老年(n = 11)和年轻老年(n = 7)的PD受试者以及对照组(n = 16,n = 9)完成了记忆扫描任务的固定集和可变集版本。未发现PD患者存在信息处理速度减慢的证据。这些结果表明,在记忆扫描任务中,PD对信息处理速度的影响不与年龄或任务版本相互作用。研究得出结论,记忆扫描任务无法检测到PD患者存在任何认知减慢的情况。

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