Xu Z L, Guo J H, Song S T
Beijing High Medical Training School.
Zhonghua Zhong Liu Za Zhi. 1994 Jul;16(4):280-3.
The effects of Lisheng-Se (Seleninized wheat germ) on metallothionein (MT) induction, lethal systemic toxicity, nephrotoxicity, hemotoxicity and anticancer activity of cisplatin (CDDP), were investigated in mice. The systemic toxicity of CDDP was significantly reduced by preadministration of Lisheng-Se (P < 0.05 or P < 0.01). The protective effects were better than its inorganic form (Na2SeO3) and Bi (BSN), (0.05 < P < 0.1). The MT level in the liver, kidney, heart and tumor tissues of mice treated with one of those compounds was determined. The results show that the levels of MT induced by Lisheng-Se were significantly increased in liver and kidney (P < 0.01 and P < 0.05). It was just in conformity with the conclusion that the best protective effect appeared in the groups treated with Lisheng-Se. These results suggest that increased MT synthesis in the liver and kidney may be involved in the protective effects of Lisheng-Se tested on the lethal toxicity, nephrotoxicity and hemotoxicity produced by CDDP. The experiments also show that Lisheng-Se did not affect the anticancer activity of CDDP in vitro and in vivo, while the MT level was not increased in cancer (P < 0.05), so Lisheng-Se might not only improve the therapeutic index of CDDP, but also did not cause drug-resistance of cancer cells.
研究了力生硒（硒化麦胚）对顺铂（CDDP）诱导金属硫蛋白（MT）、致死性全身毒性、肾毒性、血液毒性及抗癌活性的影响。预先给予力生硒可显著降低CDDP的全身毒性（P<0.05或P<0.01）。其保护作用优于无机形式的硒（亚硒酸钠）和铋（BSN）（0.05<P<0.1）。测定了用这些化合物之一处理的小鼠肝脏、肾脏、心脏和肿瘤组织中的MT水平。结果表明，力生硒诱导的肝脏和肾脏中MT水平显著升高（P<0.01和P<0.05）。这与力生硒处理组出现最佳保护作用的结论一致。这些结果表明，肝脏和肾脏中MT合成增加可能与力生硒对CDDP产生的致死毒性、肾毒性和血液毒性的保护作用有关。实验还表明，力生硒在体外和体内均不影响CDDP的抗癌活性，而肿瘤中MT水平未升高（P<0.05），因此力生硒可能不仅提高了CDDP的治疗指数，而且不会导致癌细胞产生耐药性。
