Xu Z L, Guo J H, Song S T, Li M J, Wu D Z
Cancer Research Center, North Taiping Road Hospital, Beijing.
Yao Xue Xue Bao. 1993;28(8):567-71.
The preventive effects of Zn Glycyrrhizate (Gly-Zn) on lethal toxicity, nephrotoxicity, hemotoxicity, testicular toxicity and anticancer activity of cisplatin (CDDP) were investigated in mice. The toxicity of CDDP evaluated by the above criterion was significantly reduced by preadministration of Gly-Zn 400 mg.kg-1.d-1 x 5 (P < 0.05 or P < 0.01). The protective effects were better than bismuth subnitrate (BSN) which has been studied previously (0.05 < P < 0.1). The metallothionein (MT) level in the liver, kidney, heart and cancer of mice treated with one of these compounds were determined. The results showed that the levels of MT induced by Gly-Zn were significantly increased in liver and kidney (P < 0.05). It was just in conformity with the conclusion that the best protective effect appeared in the groups treated with preadministration of Gly-Zn. These results suggest that increased MT synthesis in the liver and kidney may be involved in the protective effect of Gly-Zn on the toxicities produced by CDDP. The experiments also showed that Gly-Zn did not affect the anticancer effect of CDDP in vitro and in vivo, while the MT level was not increased in cancer (P < 0.05), so Gly-Zn might improve the therapeutic index of CDDP.
研究了甘草酸锌（Gly-Zn）对顺铂（CDDP）所致小鼠致死毒性、肾毒性、血液毒性、睾丸毒性及抗癌活性的预防作用。预先给予400 mg·kg-1·d-1×5的Gly-Zn可显著降低按上述标准评估的CDDP毒性（P<0.05或P<0.01）。其保护作用优于先前已研究的次硝酸铋（BSN）（0.05<P<0.1）。测定了用这些化合物之一处理的小鼠肝脏、肾脏、心脏及癌组织中的金属硫蛋白（MT）水平。结果显示，Gly-Zn诱导的MT水平在肝脏和肾脏中显著升高（P<0.05）。这与预先给予Gly-Zn处理的组中出现最佳保护作用的结论一致。这些结果表明，肝脏和肾脏中MT合成增加可能参与了Gly-Zn对CDDP所致毒性的保护作用。实验还表明，Gly-Zn在体外和体内均不影响CDDP的抗癌作用，而癌组织中的MT水平未升高（P<0.05），因此Gly-Zn可能提高CDDP的治疗指数。
