Wen Q S, Zhang G Z, Kong X T
Changzheng Hospital, Second Military Medical University, Shanghai.
Zhonghua Zhong Liu Za Zhi. 1994 Jul;16(4):299-301.
The modulation effects of cimetidine on the production of IL-2 and IFN-gamma by the peripheral blood mononuclear cells in 31 patients with gastric cancer and 32 normal subjects were studied. Their T lymphocyte subsets were also assayed. The IL-2 and IFN-gamma activity in patients were significantly lower than that in normal subjects (P < 0.01). Cimetidine could significantly promote IL-2 and IFN-gamma production. There was a significant negative correlation between OKT8 subsets and the activity of IL-2 and IFN-gamma (P < 0.01). The results showed that cimetidine could be used as an adjunct in the treatment of advanced neoplasm.
研究了西咪替丁对31例胃癌患者和32例正常受试者外周血单个核细胞产生白细胞介素-2（IL-2）和γ干扰素（IFN-γ）的调节作用。同时检测了他们的T淋巴细胞亚群。患者的IL-2和IFN-γ活性显著低于正常受试者（P<0.01）。西咪替丁可显著促进IL-2和IFN-γ的产生。OKT8亚群与IL-2和IFN-γ活性之间存在显著负相关（P<0.01）。结果表明，西咪替丁可作为晚期肿瘤治疗的辅助药物。
