Funda D, Smetana K, Holub M, Sýkora V
Department of Anatomy, First Faculty of Medicine, Charles University, Praha.
Folia Biol (Praha). 1994;40(3):135-40.
Ossification in 4-week-old nu/nu and nu/+ BALB/c and BFU mice was studied by X-ray analysis and by measurement of the thickness of the proximal tibial growth cartilage using CUE 4 Olympus computer image analysis. Not only altered architecture but also a significantly thinner proximal tibial growth plate was observed in athymic nu/nu as opposed to nu/+ and BFU mice. On the other hand, no significant differences were found between nu/+ and BFU littermates. Higher X-ray density of tail vertebrae was observed in nu/+ and BFU than in nu/nu mice. This comparison between athymic nu/nu and hairless euthymic BFU mice indicates that altered postnatal ossification in nude mice is not caused by hairlessness, but is due to other (immunological or endocrinological) differences.
通过X射线分析以及使用奥林巴斯CUE 4计算机图像分析测量胫骨近端生长软骨的厚度，对4周龄的裸鼠（nu/nu）、杂合子裸鼠（nu/+）以及无毛裸鼠（BFU）的骨化情况进行了研究。与nu/+和BFU小鼠相比，无胸腺的nu/nu小鼠不仅骨骼结构发生改变，胫骨近端生长板也明显更薄。另一方面，nu/+和BFU同窝仔鼠之间未发现显著差异。与nu/nu小鼠相比，nu/+和BFU小鼠尾椎的X射线密度更高。无胸腺的nu/nu小鼠与无毛有胸腺的BFU小鼠之间的这种比较表明，裸鼠出生后骨化改变并非由无毛引起，而是由于其他（免疫或内分泌）差异所致。
