Sakita K, Hoshi S, Ninomiya H, Inomata T
Department of Laboratory Animal Science, Azabu University, Kanagawa, Japan.
Exp Anim. 1999 Jan;48(1):47-50. doi: 10.1538/expanim.48.47.
Fetal thyroid follicular cells of congenitally athymic nude mouse (BALB/cAnNCrj-nu/nu) were studied with an electron microscope. The area of the entire cell, nucleus and mitochondrion were measured and compared in athymic and euthymic fetal nude mice (BALB/cAnNCrj-nu/+) at 18 days of gestation. The mean area of cytoplasm was significantly smaller in homozygous athymic nude mice than in heterozygous euthymic ones. The mean area of the mitochondrion was also smaller in homozygous athymic nude mice, but the difference was not statistically significant. There was no significant difference between the two groups in the area of the nucleus. These findings suggest that the thyroid gland of athymic nude mice is still underdeveloped at the end of gestation as compared to that of their euthymic littermates.
用电子显微镜研究了先天性无胸腺裸鼠（BALB/cAnNCrj-nu/nu）的胎儿甲状腺滤泡细胞。在妊娠18天时，测量并比较了无胸腺胎儿裸鼠（BALB/cAnNCrj-nu/+）和有胸腺胎儿裸鼠的整个细胞、细胞核和线粒体的面积。纯合无胸腺裸鼠的细胞质平均面积明显小于杂合有胸腺裸鼠。纯合无胸腺裸鼠的线粒体平均面积也较小，但差异无统计学意义。两组的细胞核面积无显著差异。这些发现表明，与有胸腺的同窝仔鼠相比，无胸腺裸鼠的甲状腺在妊娠末期仍发育不全。
