Terézhalmy G T, Pyle M A
Department of Dentistry, Cleveland Clinic Foundation, Ohio.
Dent Clin North Am. 1994 Oct;38(4):769-83.
It has been emphasized repeatedly that drugs seldom exert their beneficial effects without also causing adverse side effects. The frequency of clinically important adverse effects is difficult to estimate, but the potential for drug-drug and drug-disease interactions and drug-induced illness is high and lends credence to the statement that there are no safe biologically active agents.