Paunovich E D, Sadowsky J M, Carter P
Clinical Oral Health Programs, South Texas Veterans Healthcare System, University of Texas Health Science Center, San Antonio 78284, USA.
Dent Clin North Am. 1997 Oct;41(4):699-726.
The high prevalence of multiple chronic medical conditions in the elderly and the likelihood of multiple drug therapies dramatically increase the chance of drug-specific adverse effects and drug-drug interactions. This article reviews the age-associated alterations in pharmacokinetics and pharmacodynamics along with the most frequently prescribed medications for the elderly. Adverse drug reactions, drug-drug interactions and oral side effects are reviewed along with the impact these medications may have on dental treatment planning and management.
老年人中多种慢性疾病的高患病率以及多种药物治疗的可能性，极大地增加了药物特异性不良反应和药物相互作用的发生几率。本文回顾了与年龄相关的药代动力学和药效学变化，以及老年人最常开具的药物。还回顾了药物不良反应、药物相互作用和口腔副作用，以及这些药物可能对牙科治疗计划和管理产生的影响。
