四种人源VH1样蛋白酪氨酸磷酸酶的染色体定位
Chromosomal localization of four human VH1-like protein-tyrosine phosphatases.
作者信息
Martell K J, Kwak S, Hakes D J, Dixon J E, Trent J M
机构信息
Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109.
出版信息
Genomics. 1994 Jul 15;22(2):462-4. doi: 10.1006/geno.1994.1411.
Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and fluorescence in situ hybridization. The genes were localized to unique regions of different chromosomes: CL100, a stress-induced PTPase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11;hVH-3 to 10q25; and hVH-4 to 10q11.
通过对基因组文库进行低严谨度筛选，克隆出了4个VH1样亚类的人类蛋白质酪氨酸磷酸酶（PTPase）基因。通过G显带和荧光原位杂交将这些基因定位到各自的染色体上。这些基因定位于不同染色体的独特区域：应激诱导的PTPase CL100定位于5q35；丝裂原诱导的核PTPase PAC-1定位于2q11；hVH-3定位于10q25；hVH-4定位于10q11。
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