Panta Prashanth, Venna Venkat Raghavender
Department of Oral Medicine and Radiology, MNR Dental College and Hospital, Narsapur Road, Sangareddy, Telangana 502294, India.
Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA.
Anal Cell Pathol (Amst). 2014;2014:450629. doi: 10.1155/2014/450629. Epub 2014 Dec 10.
Oral squamous cell carcinomas (OSCC) are common malignancies that affect almost a million people every year. The key issue in reducing mortality and morbidity associated with OSCC is to develop novel strategies to identify OSCC at an early stage. One such strategy is the identification of biomarkers. So far, more than 100 biomarkers are recognized in the detection of oral cancer and they range from proteins to nucleic acids (DNAs, RNAs). Detection of ribose nucleic acids in saliva is a recent trend in diagnosing oral cancer. Studies have shown statistically significant changes in the levels of salivary transcriptomes in patients with oral squamous cell carcinomas. These biomarkers have displayed high sensitivity and specificity. Also, new point-of-care platforms such as oral fluid nanosensor test are now available that will soon emerge as chair-side tools for early detection of oral cancer. The aim of this review is to highlight the importance of salivary transcriptomes in oral cancer detection.
口腔鳞状细胞癌（OSCC）是常见的恶性肿瘤，每年影响近100万人。降低与OSCC相关的死亡率和发病率的关键问题是制定新策略以在早期阶段识别OSCC。一种这样的策略是识别生物标志物。到目前为止，在口腔癌检测中已识别出100多种生物标志物，它们从蛋白质到核酸（DNA、RNA）不等。检测唾液中的核糖核酸是诊断口腔癌的最新趋势。研究表明，口腔鳞状细胞癌患者唾液转录组水平有统计学上的显著变化。这些生物标志物显示出高敏感性和特异性。此外，诸如口腔液体纳米传感器测试等新的即时检测平台现已可用，它们很快将成为用于早期检测口腔癌的床边工具。本综述的目的是强调唾液转录组在口腔癌检测中的重要性。
