Mellins C A, Levenson R L, Zawadzki R, Kairam R, Weston M
Columbia University, New York, New York.
J Pediatr Psychol. 1994 Oct;19(5):617-27. doi: 10.1093/jpepsy/19.5.617.
Examined the effects of HIV infection and prenatal drug exposure on infant neurodevelopmental functioning. Three groups of infants were compared: HIV-infected infants, seroreverters, and a comparison group who were prenatally exposed to drugs, but not HIV. Two thirds of the HIV-infected and seroreverter infants were prenatally drug-exposed. Infants (ages 4-30 months) were administered the Bayley Scales of Infant Development. Children who were both HIV-infected and prenatally drug exposed performed significantly lower on both the mental and psychomotor scales of the Bayley. Drug exposure and neurological dysfunction were associated with mental development, whereas neurological dysfunction, drug exposure, and HIV status were associated with psychomotor development.
研究了艾滋病毒感染和产前药物暴露对婴儿神经发育功能的影响。比较了三组婴儿：感染艾滋病毒的婴儿、血清学逆转者，以及产前暴露于药物但未感染艾滋病毒的对照组。三分之二感染艾滋病毒和血清学逆转的婴儿产前暴露于药物。对年龄在4至30个月的婴儿进行了贝利婴儿发育量表测试。同时感染艾滋病毒和产前暴露于药物的儿童在贝利量表的智力和心理运动量表上的得分显著较低。药物暴露和神经功能障碍与智力发育有关，而神经功能障碍、药物暴露和艾滋病毒感染状况与心理运动发育有关。
