Williams K, MacLean C
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada.
J Reprod Med. 1994 Sep;39(9):685-8.
This study compared the effect of a change in maternal posture on maternal cerebral blood flow velocity assessed transcranially in normal vs. various hypertensive groups. Ten normotensive, 10 preeclamptic and 10 chronically hypertensive patients had maternal middle cerebral artery (MCA) blood flow velocity assessed in three positions--left lateral decubitus, supine and sitting upright--using 2-mHz transcranial Doppler ultrasound. Comparison was then made of the effect of a change in posture on cerebral blood flow velocity in each group using analysis of variance with Student's t test for statistical significance. Normotensive and chronically hypertensive women showed minimal changes in MCA blood flow velocity, while preeclamptic women showed a 30% rise in all aspects of MCA blood flow velocity from the left lateral decubitus to sitting up. In preeclamptic women, MCA blood flow velocity, which showed a significant rise with changes in posture, was not accompanied by significant changes in blood pressure and so is not a secondary response to a change in cardiac output but may be a primary effect of local circulatory changes.
本研究比较了在正常组与不同高血压组中，母亲姿势改变对经颅评估的母亲脑血流速度的影响。10名血压正常者、10名先兆子痫患者和10名慢性高血压患者，使用2兆赫兹经颅多普勒超声，在三个体位——左侧卧位、仰卧位和直立位——评估母亲大脑中动脉（MCA）的血流速度。然后，通过方差分析和学生t检验比较每组中姿势改变对脑血流速度的影响，以确定统计学意义。血压正常和慢性高血压女性的MCA血流速度变化极小，而先兆子痫女性从左侧卧位到坐起时，MCA血流速度各方面均升高30%。在先兆子痫女性中，MCA血流速度随姿势改变显著升高，但血压无显著变化，因此这不是心输出量变化的继发反应，而可能是局部循环变化的主要作用。
