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同义替换集中在肠道细菌基因中。

Synonymous substitutions are clustered in enterobacterial genes.

作者信息

Eyre-Walker A

机构信息

Department of Biological Sciences, Rutgers University, Piscataway, NJ 08855-1059.

出版信息

J Mol Evol. 1994 Nov;39(5):448-51. doi: 10.1007/BF00173413.

DOI:10.1007/BF00173413
PMID:7807534
Abstract

The spatial distribution of synonymous substitutions in enterobacterial genes is investigated. It is shown that synonymous substitutions are significantly clustered in such a way that a synonymous substitution in one codon elevates the rate of synonymous substitution in an adjacent codon by about 10%. The level of clustering does not appear to be related to the level of gene expression, and it is restricted to a range of two or three codons. There are at least three possible explanations: (1) sequence-directed mutagenesis, (2) recombination, and (3) selection.

摘要

研究了肠杆菌基因中同义替换的空间分布。结果表明，同义替换显著聚集，使得一个密码子中的同义替换会使相邻密码子的同义替换率提高约10%。聚集水平似乎与基因表达水平无关，且仅限于两到三个密码子的范围。至少有三种可能的解释：（1）序列定向诱变，（2）重组，（3）选择。

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1
Synonymous substitutions are clustered in enterobacterial genes.同义替换集中在肠道细菌基因中。
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2
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本文引用的文献

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How clonal are bacteria?细菌的克隆性如何？
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4384-8. doi: 10.1073/pnas.90.10.4384.
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Reduced synonymous substitution rate at the start of enterobacterial genes.肠杆菌基因起始处同义替换率降低。
Nucleic Acids Res. 1993 Sep 25;21(19):4599-603. doi: 10.1093/nar/21.19.4599.
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Codon usage in bacteria: correlation with gene expressivity.细菌中的密码子使用：与基因表达能力的相关性
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Codon usage and tRNA content in unicellular and multicellular organisms.单细胞和多细胞生物体中的密码子使用情况和tRNA含量。
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Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes.序列定向诱变：来自人类α-干扰素基因系统发育史的证据。
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8577-81. doi: 10.1073/pnas.82.24.8577.
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Evidence for local DNA influences on patterns of substitutions in the human alpha-interferon gene family.局部DNA对人类α-干扰素基因家族中替换模式影响的证据。
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The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.密码子适应指数——一种定向同义密码子使用偏好性的度量方法及其潜在应用。
Nucleic Acids Res. 1987 Feb 11;15(3):1281-95. doi: 10.1093/nar/15.3.1281.
9
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias.肠杆菌基因中的同义替换率与密码子使用偏好呈负相关。
Mol Biol Evol. 1987 May;4(3):222-30. doi: 10.1093/oxfordjournals.molbev.a040443.
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Multiple base-pair mutations in yeast.
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