Iwata M, Ida M, Kita T, Horiguchi T, Sato A
Department of Respiratory Medicine, Haibara General Hospital, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Aug;32(8):803-8.
We report the first case of respiratory bronchiolitis-associated interstitial lung disease in Japan. A 48-year-old man with a 36-pack-year smoking history was referred because of 6 months of dry cough. Chest X-ray showed bilateral reticulonodular shadows. HRCT scan showed bilateral reticulonodular and ground glass shadows with centrilobular distribution. BAL yielded 85 x 10(6) cells with 99.5% macrophages. Histologic examination of the biopsy specimen obtained under thoracoscopy showed evidence of respiratory bronchiolitis, with accumulation of pigmented macrophages within respiratory bronchioles and adjacent air spaces associated with mild thickening of the peribronchiolar interstitium.
我们报告了日本首例呼吸性细支气管炎相关间质性肺疾病病例。一名有36年吸烟史、48岁的男性因干咳6个月前来就诊。胸部X光显示双侧网状结节状阴影。高分辨率CT扫描显示双侧呈小叶中心分布的网状结节状及磨玻璃样阴影。支气管肺泡灌洗获得85×10⁶个细胞，其中99.5%为巨噬细胞。经胸腔镜获取的活检标本组织学检查显示有呼吸性细支气管炎的证据，呼吸性细支气管及相邻气腔内有色素沉着巨噬细胞积聚，伴有细支气管周围间质轻度增厚。
