Ishida Y, Riesinger I, Wallimann T, Paul R J
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Mol Cell Biochem. 1994 Apr-May;133-134:39-50. doi: 10.1007/BF01267946.
The phosphocreatine content of smooth muscle is of similar magnitude to ATP. Thus the function of the creatine kinase system in this tissue cannot simply be regarded as an energy buffer. Thus an understanding of its role in smooth muscle behavior can point to CK function in other systems. From our perspective CK function in smooth muscle is one example of a more general phenomenon, that of the co-localization of ATP synthesis and utilization. In an interesting and analogous fashion distinct glycolytic cascades are also localized in regions of the cell with specialized energy requirements. Similar to CK, glycolytic enzymes are known to be localized on thin filaments, sarcoplasmic reticulum and plasma membrane. In this chapter we will describe the relations between glycolysis and smooth muscle function and compare and contrast to that of the CK system. Our goal is to more fully understand the significance of the compartmentation of distinct pathways for ATP synthesis with specific functions in smooth muscle. This organization of metabolism and function seen most clearly in smooth muscle is likely representative of many other cell types.
平滑肌中的磷酸肌酸含量与三磷酸腺苷（ATP）的含量相近。因此，肌酸激酶系统在该组织中的功能不能简单地被视为一种能量缓冲。所以，了解其在平滑肌行为中的作用可以揭示肌酸激酶在其他系统中的功能。从我们的角度来看，平滑肌中的肌酸激酶功能是一个更普遍现象的例子，即ATP合成与利用的共定位。以一种有趣且类似的方式，不同的糖酵解级联反应也定位于细胞中具有特定能量需求的区域。与肌酸激酶类似，已知糖酵解酶定位于细肌丝、肌浆网和质膜上。在本章中，我们将描述糖酵解与平滑肌功能之间的关系，并与肌酸激酶系统进行比较和对比。我们的目标是更全面地理解平滑肌中不同ATP合成途径与特定功能区室化的意义。这种在平滑肌中最明显的代谢和功能组织方式可能代表了许多其他细胞类型。
