Dudkin K N, Kruchinin V K, Chueva I V
Laboratory of the Regulation of the Functions of Brain Neurons, I. P Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
Neurosci Behav Physiol. 1994 Jul-Aug;24(4):341-50. doi: 10.1007/BF02360202.
Monkeys performed a task of delayed visual differentiation of differently colored stimuli in behavioral experiments. The impulse activity of individual neurons of the prefrontal and inferotemporal cortex before and after the systemic administration of a blocker of M-cholinoreceptors, amyzil (0.8-1.0 mg/kg), was recorded simultaneously. Deterioration of the characteristics of recognition induced by amyzil was accompanied mainly by a significant increase in the activity of neurons of the prefrontal cortex which was dependant on the stage of recognition, and intensified with an increase in the delay interval. The impulse activity of the neurons of the inferotemporal cortex varied in the process without a regular pattern: at some stages of recognition it increased, at others it was inhibited. Amyzil induced a substantial decrease in the coefficients of cross correlation between the simultaneous respondent reactions of groups of neurons of the prefrontal and inferotemporal cortex. The results obtained point to the fact that the cholinergic structures of the inferotemporal and prefrontal cortex participate, at various stages of visual recognition in monkeys, in the formation of the dynamic functional systems which make their specific contribution to informational processes.
在行为实验中，猴子执行了一项对不同颜色刺激进行延迟视觉辨别的任务。同时记录了在全身给予M-胆碱受体阻滞剂氨甲酰胆碱（0.8 - 1.0毫克/千克）前后，前额叶和颞下皮质单个神经元的冲动活动。氨甲酰胆碱引起的识别特征恶化主要伴随着前额叶皮质神经元活动的显著增加，这取决于识别阶段，并随着延迟间隔的增加而增强。颞下皮质神经元的冲动活动在这个过程中变化无规律：在识别的某些阶段增加，在其他阶段受到抑制。氨甲酰胆碱导致前额叶和颞下皮质神经元群同时反应之间的互相关系数大幅下降。所获得的结果表明，在猴子视觉识别的不同阶段，颞下皮质和前额叶皮质的胆碱能结构参与了动态功能系统的形成，这些系统对信息过程做出了特定贡献。
