Röcken C, Saeger W, Linke R P
Department of Pathology, Marienkrankenhaus, Hamburg, Germany.
Pathol Res Pract. 1994 Aug;190(7):641-9. doi: 10.1016/S0344-0338(11)80742-9.
The prevalence of gastrointestinal amyloid was determined in 110 consecutive autopsy patients aged 85 years and older. Paraffin sections from the esophagus, stomach, small intestine, colon and rectum were stained with Congo red and inspected in polarized light. Amyloid was found in 38 patients (36%). Four patients had generalized amyloidosis and the remaining 34 revealed more localized varieties of amyloid. Immunohistochemical classification with a panel of antisera directed against five major amyloid fibril proteins displayed at least four different types of amyloid. Twenty cases exhibited amyloid of transthyretin origin, five cases were of lambda light chain origin and one case was of amyloid A-type. Thus far, unclassifiable amyloid deposits were found in 18 cases, 16 of which were strictly localized in subserosal veins. This consecutive autopsy series was compared with 98 randomly-selected bioptical gastrointestinal tissues with amyloid according to distribution pattern, sex, frequency of the various types of amyloid and associated diseases.
对110例年龄在85岁及以上的连续尸检患者进行了胃肠道淀粉样变患病率的测定。取自食管、胃、小肠、结肠和直肠的石蜡切片用刚果红染色，并在偏振光下检查。38例患者（36%）发现有淀粉样变。4例患者患有全身性淀粉样变，其余34例显示出更局限的淀粉样变类型。用一组针对五种主要淀粉样纤维蛋白的抗血清进行免疫组织化学分类，显示至少有四种不同类型的淀粉样变。20例表现为转甲状腺素蛋白源性淀粉样变，5例为λ轻链源性，1例为淀粉样蛋白A 型。迄今为止，18例发现了无法分类的淀粉样沉积物，其中16例严格局限于浆膜下静脉。根据分布模式、性别、各种类型淀粉样变的频率以及相关疾病，将这个连续尸检系列与98例随机选择的有淀粉样变的胃肠道活检组织进行了比较。
