Nawrocki B, Polette M, Clavel C, Morrone A, Eschard J P, Etienne J C, Birembaut P
I.N.S.E.R.M. U.314, Hôpital Maison Blanche, C.H.U. de Reims, France.
Pathol Res Pract. 1994 Aug;190(7):690-6. doi: 10.1016/S0344-0338(11)80748-X.
Rheumatoid hyperplastic synovial lining cells and sublining fibroblasts are known to produce, in vivo and in vitro, matrix metallo-proteinases which degrade extracellular matrix components of joints. We have studied by immunohistochemistry and in situ hybridization the presence of matrix metallo-proteinase stromelysin 3 and its potential inhibitors TIMP-1 and TIMP-2 in 5 cases of normal synovia, 5 cases of chronic synovitis and 12 cases of rheumatoid arthritis. Few hyperplastic synoviocytes and some sparse fibroblasts have been found to produce stromelysin 3 in all rheumatoid arthritis and 2 chronic synovitis. Stromelysin 3 seems to have a limited role in the destructive process of extracellular matrix. TIMP-1 and TIMP-2 were largely expressed principally in hyperplastic synoviocytes and in endothelial cells of all rheumatoid synovitis and 2 chronic synovitis. These findings plead for a balance between matrix metallo-proteinases and their inhibitors in these inflammatory lesions.
已知类风湿增生性滑膜衬里细胞和滑膜下层成纤维细胞在体内和体外均能产生降解关节细胞外基质成分的基质金属蛋白酶。我们通过免疫组织化学和原位杂交研究了5例正常滑膜、5例慢性滑膜炎和12例类风湿关节炎中基质金属蛋白酶基质溶解素3及其潜在抑制剂TIMP - 1和TIMP - 2的存在情况。在所有类风湿关节炎病例和2例慢性滑膜炎病例中，发现少数增生的滑膜细胞和一些稀疏的成纤维细胞产生基质溶解素3。基质溶解素3在细胞外基质的破坏过程中似乎作用有限。TIMP - 1和TIMP - 2主要在所有类风湿滑膜炎和2例慢性滑膜炎的增生滑膜细胞和内皮细胞中大量表达。这些发现表明在这些炎症病变中基质金属蛋白酶与其抑制剂之间存在平衡。
