Drut R, Drut R M
Servicio de Patología, Hospital de Niños, La Plata, Argentina.
Pediatr Pathol. 1994 Sep-Oct;14(5):863-72. doi: 10.3109/15513819409037683.
A 7-year-old boy had undergone kidney transplantation for chronic renal failure secondary to bilateral renal hypoplasia. He developed acute and chronic rejection and received immunosuppressive therapy. A year later he died with EBV-associated hemophagocytic syndrome. The main pathologic findings disclosed visceral (lung and stomach) and abdominal lymph node involvement of Kaposi's sarcoma and EBV-positive immunoblasts in several organs. In the lungs and lymph nodes these had the features of polymorphous lymphoimmunoblastic lesions. Because of the peculiar distribution of Kaposi's sarcoma lesions a pathogenetic hypothesis is proposed based on the site of entry of the virus. This case contributes to expanding the relationship between Kaposi's sarcoma and kidney transplantation in the pediatric population.
一名7岁男孩因双侧肾发育不全继发慢性肾衰竭接受了肾移植。他发生了急性和慢性排斥反应，并接受了免疫抑制治疗。一年后，他死于与EB病毒相关的噬血细胞综合征。主要病理发现显示，卡波西肉瘤累及内脏（肺和胃）及腹部淋巴结，多个器官中有EB病毒阳性免疫母细胞。在肺和淋巴结中，这些病变具有多形性淋巴免疫母细胞病变的特征。由于卡波西肉瘤病变的特殊分布，基于病毒的进入部位提出了一种发病机制假说。该病例有助于拓展儿童人群中卡波西肉瘤与肾移植之间的关系。
