螺旋-转角-螺旋、探测螺旋、激素受体和锌指家族中转录因子的DNA识别密码。
DNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families.
作者信息
Suzuki M, Yagi N
机构信息
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12357-61. doi: 10.1073/pnas.91.26.12357.
Abstract
We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We have incorporated these rules into a computer program and examined the nature of the rules. Here we conclude that the DNA recognition rules are simple, logical, and consistent. The rules are specific enough to predict DNA-binding characteristics from a protein sequence.
摘要
我们之前报道过，在四个转录因子家族中，DNA识别规则可描述为：（i）化学规则，列出了20种氨基酸残基与四种DNA碱基之间可能的配对；（ii）立体化学规则，描述了相互接触的碱基和氨基酸位置。我们已将这些规则纳入一个计算机程序，并研究了这些规则的性质。在此我们得出结论，DNA识别规则简单、符合逻辑且一致。这些规则足够具体，能够从蛋白质序列预测DNA结合特性。
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