合成能够复性以识别给定靶分子的杂聚物的热力学方法。
Thermodynamic procedure to synthesize heteropolymers that can renature to recognize a given target molecule.
作者信息
Pande V S, Grosberg A Y, Tanaka T
机构信息
Department of Physics, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12976-9. doi: 10.1073/pnas.91.26.12976.
We suggest a procedure to synthesize polymers with characteristics similar to those observed in globular proteins: renaturability and the existence of an "active site" capable of specifically recognizing a given target molecule. This procedure is investigated by computer simulation, which finds a yield of up to 65%. We believe that, in principle, this scheme can be realized in vitro. The applicability of this approach as a model of prebiotic synthesis in vivo is also discussed.
我们提出了一种合成聚合物的方法，该聚合物具有与球状蛋白质中观察到的特性相似的特征：可复性以及存在能够特异性识别给定目标分子的“活性位点”。通过计算机模拟对该方法进行了研究，模拟结果显示产率高达65%。我们认为，原则上该方案可以在体外实现。还讨论了这种方法作为体内益生元合成模型的适用性。
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