Ina Y, Takada K, Noda M, Satou T, Hashiba H, Miyachi A, Ito S, Iijima N, Yamamoto M
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Mar;29(3):316-21.
Serum levels of soluble IL-2 receptors (sIL-2R) by an ELISA method in 28 patients with sarcoidosis and 16 healthy controls were studied, and the source of sIL-2R was further examined. sIL-2R in serum was significantly higher in sarcoidosis than in controls. In sarcoidosis sIL-2R in serum significantly correlated with serum ACE level, and was significantly higher in stage II or III patients than in stage O patients. sIL-2R in supernatants of cultured monocytes (Mo) and alveolar macrophages (AM) was significantly higher in sarcoidosis than in controls. sIL-2R in supernatants of cultured T lymphocytes obtained from peripheral blood or BALF was barely detectable in sarcoidosis, while it was undetectable in controls. Furthermore, sIL-2R in serum was significantly correlated with sIL-2R in supernatants of cultured Mo and AM. These results indicate that sIL-2R in serum is an useful index of the disease activity of sarcoidosis, and may be mainly derived from IL-2R on Mo and AM.
采用酶联免疫吸附测定法（ELISA）研究了28例结节病患者和16名健康对照者血清中可溶性白细胞介素-2受体（sIL-2R）水平，并进一步检测了sIL-2R的来源。结节病患者血清中的sIL-2R显著高于对照组。在结节病中，血清sIL-2R与血清血管紧张素转换酶（ACE）水平显著相关，且Ⅱ期或Ⅲ期患者的血清sIL-2R显著高于0期患者。结节病患者培养的单核细胞（Mo）和肺泡巨噬细胞（AM）上清液中的sIL-2R显著高于对照组。结节病患者外周血或支气管肺泡灌洗液（BALF）中培养的T淋巴细胞上清液中的sIL-2R几乎检测不到，而对照组中则未检测到。此外，血清中的sIL-2R与培养的Mo和AM上清液中的sIL-2R显著相关。这些结果表明，血清sIL-2R是结节病疾病活动的一个有用指标，且可能主要来源于Mo和AM上的IL-2R。
