Harada H, Shijubo N, Katoh S, Satoh M, Abe S
Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Sarcoidosis. 1994 Sep;11(2):132-4.
We report an unusual case of non-Hodgkin T cell lymphoma associated with sarcoidosis. A 44-year-old woman was histologically diagnosed as having sarcoidosis in 1966. Diffuse interstitial lung disease and erythematous skin nodules disappeared following steroid therapy. Twenty years after sarcoidosis onset erythematous nodosum recurred and biopsy specimens revealed non caseating epithelioid granuloma. Thirty-seven months later a malignant T cell lymphoma developed in the skin portion where sarcoid lesions recurred. We discuss the possible relationship between the sarcoid inflammatory process and the development of a malignant T cell clone as origin of the T cell lymphoma.
我们报告了一例罕见的与结节病相关的非霍奇金T细胞淋巴瘤病例。一名44岁女性在1966年经组织学诊断为结节病。弥漫性间质性肺病和皮肤红斑结节在类固醇治疗后消失。结节病发病20年后，结节性红斑复发，活检标本显示非干酪样上皮样肉芽肿。37个月后，在结节病复发的皮肤部位发生了恶性T细胞淋巴瘤。我们讨论了结节病炎症过程与作为T细胞淋巴瘤起源的恶性T细胞克隆发展之间的可能关系。
