Joshi V V, Silverman J F
Department of Pathology, East Carolina University School of Medicine, Greenville, NC 27858-4354.
Semin Diagn Pathol. 1994 May;11(2):107-17.
Histogenesis, basic histologic features, nomenclature, and criteria for diagnosis and prognostic classifications based on morphological features of neuroblastic tumors (NTs) are described. NTs that arise from neuroectodermal cells of the adrenal medulla and sympathetic ganglia recapitulate the development of sympathetic ganglion. The following three basic types of NTs are recognized: neuroblastoma (NBs) and ganglioneuroblastomas (GNBs) and ganglioneuromas (GNs). NBs can be undifferentiated, poorly differentiated or differentiating; GNBs have the following three subtypes. (1) nodular, (2) intermixed, and (3) borderline. The conventional and recommended terminology and Shimada terminology of NTs are described (Tables 1 and 2). There are three basic pathologic components of NTs, neuroblastomatous, ganglioneuromatous, and intermediate components (Figs 3, 5, and 7). There are two major prognostic classifications based on morphological features of NTs, Shimada classification and histologic grading (Tables 3 and 4).
本文描述了神经母细胞瘤（NTs）的组织发生、基本组织学特征、命名以及基于形态学特征的诊断和预后分类标准。起源于肾上腺髓质和交感神经节神经外胚层细胞的NTs重现了交感神经节的发育过程。公认的NTs有以下三种基本类型：神经母细胞瘤（NBs）、神经节神经母细胞瘤（GNBs）和神经节瘤（GNs）。NBs可以是未分化、低分化或正在分化的；GNBs有以下三种亚型：（1）结节型，（2）混合型，（3）边缘型。文中描述了NTs的传统术语、推荐术语和岛田术语（表1和表2）。NTs有三种基本病理成分，即神经母细胞瘤成分、神经节瘤成分和中间成分（图3、5和7）。基于NTs形态学特征有两种主要的预后分类，即岛田分类和组织学分级（表3和表4）。
